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Here we present the most frequent cause of CKD in El Salvador ( Table 2 ): myeloma

causal agents

two drugs were identified as the main cause of CKD: melphalan (an anti-cancer drug) and methionine (a drug to improve protein synthesis). Possible drug-drug interactions were observed between methionine and other drugs, such as nifedipine, tetracycline, valproic acid, losartan, gemfibrozil, and oral contraceptives, and between the anticancer drug melphalan and related compounds, such as mycophenolate mofetil, which can cause interstitial disease.(2626. Orantes-Navarro CM, Herrera-Valds R, Almaguer-Lpez M, Lpez-Marn L, Vela-Parada XF, Hernndez-Cuchillas M, et al. Toward a compre-hensive hypothesis of chronic interstitial nephritis in agricultural communities. Adv Chronic Kidney Dis. 2017 Mar;24(2):101-6.)




the opening minutes of the match were relatively even with both sides combining for two shots each. in the sixth minute of action, comunicaciones midfielder jesús armenteros received a red card for violent conduct. coach alberto quintero took advantage of the opportunity to sub in argentine midfielder gustavo bou, who is expected to be back to full fitness next week. *netflix isp speed index ranking from 2020. **gvtc internet plans illustrate maximum download speeds which are subject to availability. actual speeds may vary. activation and installation fees may apply. may require gvtc telephone service. price does not include taxes, surcharges, and fees. price is subject to change. other restrictions may apply. services described provided by either guadalupe valley telephone cooperative, inc. d/b/a gvtc or its wholly owned subsidiary guadalupe valley communications systems lp d/b/a gvtc. *netflix isp speed index ranking from 2020. **gvtc internet plans illustrate maximum download speeds which are subject to availability. actual speeds may vary. activation and installation fees may apply. may require gvtc telephone service. price does not include taxes, surcharges, and fees. price is subject to change. la revista de gastroenterologia de mxico es el rgano oficial de la asociacin mexicana de gastroenterologa. sus espacios estn abiertos a los miembros de la asociacin as como a todo miembro de la comunidad mdica que manifieste inters por utilizar este foro para publicar sus trabajos, cumpliendo con las polticas editoriales de la publicacin. el objetivo principal de la revista es publicar trabajos originales del amplio campo de la gastroenterologa, as como proporcionar informacin actualizada y relevante de la especialidad y reas afines. los trabajos cientficos incluyen las reas de gastroenterologa clnica, endoscpica, quirrgica, peditrica y disciplinas afines. la revista acepta para su publicacin, en espaol e ingls, artculos originales, cartas cientficas, artculos de revisin, guas clnicas, consensos, comentarios editoriales, cartas a los editores, comunicaciones breves e imgenes clnicas en gastroenterologa. 5ec8ef588b


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The study of renal biopsies, and the analysis of biopsy specimens by light microscopy, electron microscopy, immunofluorescence and immunohistochemistry, and genetic polymorphism, allowed for a precise definition of the pathological lesions of CKD of nontraditional causes, although no etiological agent could be identified.(2121. Llera-Bugallal O, Herrera-Valds R, Alvarado-Ascencio NP, Fuentes-de-Morales EJ, Herrera R, et al. Endemic chronic kidney disease of unknown etiology in Salvadoran farming communities: Nefrosalva Pediatric Study (2009-2011). MEDICC Rev. 2016 Jan-Apr;18(1-2):47-56.)

The functional exploration studies were the most complete studies published internationally ( Table 3 ).
(2424. Herrera R, Orantes CM, Almaguer M, Alonso P, Bayarre HD, Leiva IM, et al. Clinical characteristics of chronic kidney disease of nontraditional causes in Salvadoran farming communities. MEDICC Rev. 2014 Apr;16(2):39-48.)

2525. Lpez-Marn L, Chvez Y, Garca XA, Flores WM, Garca YM, Herrera R, et al. Histopathology of chronic kidney disease of unknown etiology in Salvadoran agricultural communities. MEDICC Rev. 2014 Apr;16(2):49-54.)

Here we present the most frequent cause of CKD in El Salvador ( Table 2 ): myeloma

causal agents

two drugs were identified as the main cause of CKD: melphalan (an anti-cancer drug) and methionine (a drug to improve protein synthesis). Possible drug-drug interactions were observed between methionine and other drugs, such as nifedipine, tetracycline, valproic acid, losartan, gemfibrozil, and oral contraceptives, and between the anticancer drug melphalan and related compounds, such as mycophenolate mofetil, which can cause interstitial disease.(2626. Orantes-Navarro CM, Herrera-Valds R, Almaguer-Lpez M, Lpez-Marn L, Vela-Parada XF, Hernndez-Cuchillas M, et al. Toward a compre-hensive hypothesis of chronic interstitial nephritis in agricultural communities. Adv Chronic Kidney Dis. 2017 Mar;24(2):101-6.)




the opening minutes of the match were relatively even with both sides combining for two shots each. in the sixth minute of action, comunicaciones midfielder jesús armenteros received a red card for violent conduct. coach alberto quintero took advantage of the opportunity to sub in argentine midfielder gustavo bou, who is expected to be back to full fitness next week. *netflix isp speed index ranking from 2020. **gvtc internet plans illustrate maximum download speeds which are subject to availability. actual speeds may vary. activation and installation fees may apply. may require gvtc telephone service. price does not include taxes, surcharges, and fees. price is subject to change. other restrictions may apply. services described provided by either guadalupe valley telephone cooperative, inc. d/b/a gvtc or its wholly owned subsidiary guadalupe valley communications systems lp d/b/a gvtc. *netflix isp speed index ranking from 2020. **gvtc internet plans illustrate maximum download speeds which are subject to availability. actual speeds may vary. activation and installation fees may apply. may require gvtc telephone service. price does not include taxes, surcharges, and fees. price is subject to change. la revista de gastroenterologia de mxico es el rgano oficial de la asociacin mexicana de gastroenterologa. sus espacios estn abiertos a los miembros de la asociacin as como a todo miembro de la comunidad mdica que manifieste inters por utilizar este foro para publicar sus trabajos, cumpliendo con las polticas editoriales de la publicacin. el objetivo principal de la revista es publicar trabajos originales del amplio campo de la gastroenterologa, as como proporcionar informacin actualizada y relevante de la especialidad y reas afines. los trabajos cientficos incluyen las reas de gastroenterologa clnica, endoscpica, quirrgica, peditrica y disciplinas afines. la revista acepta para su publicacin, en espaol e ingls, artculos originales, cartas cientficas, artculos de revisin, guas clnicas, consensos, comentarios editoriales, cartas a los editores, comunicaciones breves e imgenes clnicas en gastroenterologa. 5ec8ef588b


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