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A-kinase anchor proteins (AKAPs) are involved in multiple cellular processes, including signaling, transcription, and cytoskeletal organization. The human genome contains 85 genes encoding for AKAPs; some have been studied extensively and their expression and function have been demonstrated in tissues. However, many remain to be characterized. We are using the parasite Schistosoma mansoni as a model system to study the function of AKAPs. As many of these have not been characterized in any organism, we used a transcriptome approach to identify Schistosoma mansoni genes encoding for AKAPs. This analysis led to the identification of 24 genes encoding for putative AKAPs. Among them, one gene coding for a protein with four tandem PKA-binding domains and a canonical AKAP domain was strongly expressed in the testis. We named this protein AKAP4. We demonstrated that it is localized in the testis and is associated with the membrane of the flagellum, where it is part of a multiprotein complex that may be involved in the organization of the flagellum. This finding is exciting, since AKAP4 is the first AKAP to be identified in any organism. Moreover, it is the first AKAP to be found in testis. Schistosoma mansoni is the agent responsible for the pathology of the human disease schistosomiasis, and it has been used successfully as a model for many of the diseases caused by worms that infect other animals. It is the only organism that can complete its life cycle in mammals and thus it is an attractive model to investigate the molecular basis of the interaction between parasites and their hosts. We propose to study the expression of AKAP4 in Schistosoma mansoni and its potential function, and the importance of AKAP4 in the interaction between the parasite and its host. [unreadable] [unreadable] [unreadable]High-dose pemetrexed/carboplatin in elderly and refractory patients with malignant pleural mesothelioma: a phase II study. Malignant pleural mesothelioma is an aggressive tumor with a poor prognosis. Pemetrexed has shown activity in mesothelioma. To determine the efficacy and toxicity of pemetrexed, 500 mg/m(2), in combination with carboplatin, as first-line chemotherapy in elderly and refractory patients with malignant pleural mesothelioma. Twenty- ca3bfb1094
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James Carter (cricketer) James Carter (born 24 September 1872) was an English cricketer. He was a left-handed batsman and a left-arm slow bowler who played for Gloucestershire. He was born in East Peckham, Kent and died in Cheltenham, Gloucestershire on 3 April 1952. Carter made a single first-class appearance, during the 1899 season, against Worcestershire. From the lower-middle order, he scored 5 runs in the first innings in which he batted, and 10 runs in the second. External links James Carter at Cricket Archive Category:1872 births Category:1952 deaths Category:English cricketers Category:Gloucestershire cricketers28/11/2016 – 23:50 O presidente da Câmara dos Deputados, Eduardo Cunha (PMDB-RJ), foi denunciado pelo Ministério Público Federal em Brasília na tarde desta terça-feira (28) pelo crime de corrupção passiva e lavagem de dinheiro. A denúncia foi protocolada no Supremo Tribunal Federal (STF) pela Procuradoria-Geral da República. Cunha é acusado de ter recebido, em 2012, propina de R$ 5 milhões, enquanto era presidente da Câmara. As investigações apontam que o dinheiro, que teria sido enviado pelo grupo J&F (Júlio Marcelo Camargo Filho, ex-presidente da J&F e amigo de Eduardo Cunha), teria sido repassado pelo vice-presidente da empresa, o ex-deputado cassado José de Filippi (PP-PB). O peemedebista teria recebido o dinheiro do grupo J&F em espécie e a partir daí o repasse teria sido feito pessoalmente. O deputado responde ao processo porque a Procuradoria-Geral da República, ao
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Use Markup Assist to capture and show design changes in your drawings in one easy-to-use command. (video: 2:33 min.) “Drawing and showing your design changes is a big part of design and drafting,” says Senior Product Manager Grant Borchert. “Markup Assist and Import Text are major enhancements to AutoCAD that simplify the process of making changes and correcting errors, while providing a quick and accurate way to show those changes to your team.” Borchert goes on to say, “AutoCAD is a complex tool, but the best part of it is how you can use it to be more productive and efficient. Markup Assist and Import Text are major steps in that direction, taking AutoCAD to another level of usability for AutoCAD users.” Markup Assist and Import Text are included with all AutoCAD 2023 subscriptions. A free 30-day trial is available for new AutoCAD users or current users who haven’t used AutoCAD for a while. The 30-day trial gives you an opportunity to get to know the new features, so you can make an informed decision about whether you want to upgrade your subscription. When your trial expires, you’ll be automatically upgraded to the current version of AutoCAD 2023. Speed and control in CAD Drafting: Forget complicated selections and paths. With the new Multi-Select tool, your entire drawing is visible at once, with all options available to you, including the ability to select all areas of a shape. (video: 1:50 min.) Select the area you want to work on by clicking on it once, then click again on the area you want to select the shape by using the options in the Multi-Select dialog. (video: 2:04 min.) “Designing and drafting can be a challenging, time-consuming process,” says Product Manager Dan Nachum. “AutoCAD’s Multi-Select tool makes it easier to select large areas of a shape or path that would otherwise be difficult to select by hand.” The new Quick Select tool makes it easy to select large areas, using the most common approach: click once and drag to select. (video: 1:15 min.) Select the shape or area you want to modify by using the options in the Quick Select dialog box.
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